Phosphatidylcholine – Essentiale N Ampoules for Liver Health and Beyond

About Essentiale N Ampoules

Impaired liver function significantly reduces quality of life and is often reflected in appearance. Typical symptoms include swelling, frequent nausea (sometimes with vomiting), bitter taste in the mouth, yellow coating on the tongue, insomnia, constant fatigue and drowsiness, and regular pain in the right upper abdomen. These issues usually arise from excessive consumption of fatty and junk food, alcohol, certain medications, or infectious and viral diseases.

Essentiale N ampoules, containing 250 mg of essential phospholipids (EPL), help restore and stabilize liver and digestive organ function. The active ingredient — phosphatidylcholine — replaces and regenerates damaged phospholipids at the cellular level, repairing and renewing cell membranes.

The Science Behind Phosphatidylcholine

Numerous scientific studies have confirmed that phosphatidylcholine effectively protects liver cells against toxic substances such as ethanol, carbon tetrachloride, trichlorethylene (found in dry-cleaning products), and fungal toxins. Phosphatidylcholine is a key component of circulating blood lipids and the primary structural element of bile, which is essential for proper fat absorption. It also reduces dietary cholesterol absorption.

For normal liver and digestive function, cell membranes must be constantly renewed. Phosphatidylcholine serves as the main building material for hepatocytes (liver cells) and provides ongoing protection.

Key Advantages of Essentiale N Ampoules

Essentiale N ampoules offer several distinctive benefits:

• membranotropic action;
• improved metabolism;
• pronounced hepatoprotective effect;
• stabilization of carbohydrate and lipid metabolism;
• significant improvement in functional state.

Unique Composition of Essentiale Phospholipids

The active substance is the EPL substance (diglyceride esters of choline phosphoric acid — phosphatidylcholine) of natural origin. It contains approximately 70% linoleic acid, with the remaining 30% consisting of linolenic and oleic acids.

During intravenous administration, essential phospholipids quickly integrate into disturbed liver metabolism processes. They easily penetrate cell membranes and bind with endogenous phospholipids, leading to rapid clinical improvement and positive changes in laboratory parameters.

Understanding Phospholipids

Phospholipids are vital compounds in the human body that perform multiple critical functions:

• form the structural basis of cell membranes;
• facilitate transport of fats, cholesterol, and fatty acids;
• promote regeneration of damaged tissues;
• regulate cell growth and programmed cell death;
• influence the activity of various enzymes.

The body cannot synthesize sufficient phospholipids on its own; they must be obtained from food. Once absorbed, they embed into cell membranes, supporting repair. They are excreted via the biliary tract, which lowers the lithogenic index of bile and improves its regulation.

The Role of Phosphatidylcholine in the Body

The liver acts as the body’s primary filter and takes the first hit from toxins — alcohol, medications, poor-quality food and drinks, etc. Therefore, it requires restoration more often than other organs. To function like a precise clockwork mechanism, the liver needs a steady supply of phosphatidylcholine.

Higher levels of phosphatidylcholine also positively affect cognitive functions such as memory and concentration. It helps emulsify cholesterol in the blood, reducing the risk of cardiovascular disease, and promotes better fat emulsification in food for improved absorption.

Soybeans and Soy-Derived Phospholipids: A Closer Look

Legumes, especially soybeans, have been known to humanity for millennia. As early as 2838 BC, Emperor Sheng Nung described beans as one of the “five sacred grains” essential for life.

The highest natural concentrations of phosphatidylcholine are found in soybeans, other legumes, eggs, cod, beef liver, milk, and broccoli.

Today there are around 800 soybean varieties. They contain 35–40% protein, 20–30% carbohydrates, and 5–10% other compounds. Processing of soybean oil yields 30–45% soy lecithin, which is rich in phosphatidylcholine — the very component used in pharmaceutical hepatoprotectors.

Product Details

Essentiale N is supplied as a solution for intravenous administration. It is prescribed to protect and restore liver function. Each pack contains 5 ampoules of 5 ml each.

Essentiale N Ampoules: Composition (per 5 ml ampoule)

• Active ingredient: essential phospholipids (EPL substance) — 250 mg (diglyceride esters of choline phosphoric acid of natural origin with high content of unsaturated fatty acids, mainly linoleic acid ~70%, plus linolenic and oleic acids);
• Excipients: benzyl alcohol, deoxycholic acid, sodium chloride, sodium hydroxide, riboflavin (dye), water for injection.

All ingredients are certified and meet the highest quality standards.

Phosphatidylcholine IV Therapy: Benefits and Effects

Intravenous phosphatidylcholine therapy provides comprehensive benefits for liver health and overall well-being:

• restores damaged cell membranes;
• protects cells and tissues from external destructive factors;
• serves as a structural component of bile;
• accelerates fat metabolism;
• maintains healthy blood cholesterol metabolism;
• supports nerve impulse transmission from brain to muscles;
• improves brain performance;
• aids weight loss;
• reduces risk of malignant tumors, dementia, Alzheimer’s disease, and other conditions;
• transports and distributes lipids and fat-soluble vitamins;
• enhances quality of life, sleep, cognitive health, memory, and concentration.

How to Use Essentiale N Ampoules

The preparation is administered intravenously. The contents of the ampoule are preferably diluted 1:1 with the patient’s own blood. If blood dilution is not possible, electrolyte-free solutions may be used (e.g., 5% or 10% glucose solution or 5% xylitol solution, 1:1 ratio).

Recommended dosage: Adults and children — 5–10 ml/day administered slowly IV. In severe cases, the dose may be increased to 10–20 ml/day. A typical course lasts 10 days. Intravenous administration is chosen when a faster and stronger effect is needed compared to oral capsules. Sometimes capsules are prescribed simultaneously to enhance the therapeutic effect.

Storage and Handling

Shelf life: 3 years. Store in a dry place protected from children and pets at +2°C to +8°C (refrigerator recommended). Opened or partially used ampoules must be discarded and cannot be reused.

Clinical Studies and Effectiveness

Multiple clinical studies have confirmed the high efficacy of Essentiale N phospholipids. Patients report significant improvement, disappearance of liver disease symptoms, and overall better well-being after the course.

In 2016, K.J. Gundermann summarized 20 independent studies showing that phosphatidylcholine effectively relieved nausea, weakness, and bloating, with clinical improvement in ~81% of patients. Laboratory blood plasma parameters also improved significantly.

Essential phospholipids integrate into damaged cell membranes, displace defective endogenous lipids, and restore normal structure and function. They increase the liver’s resistance to pathogenic factors and enhance reparative and regenerative processes.

Safety and Legal Information

When used at doctor-recommended doses, phosphatidylcholine is safe. Essentiale N is a prescription medication and is certified in the USA.

Indications

• Fatty liver degeneration
• Cirrhosis
• Acute and chronic hepatitis of any form
• Hepatocyte necrosis
• Hepatic coma/precoma
• Toxic liver damage
• Pregnancy toxicosis
• Pre- and post-operative treatment in the hepatobiliary zone
• Psoriasis
• Neurodermatitis
• Radiation syndrome

Contraindications

• Hypersensitivity or allergy to any component
• Children under 12 years of age

Precautions

Use during pregnancy and breastfeeding only under medical supervision. Overdose may cause gastrointestinal disturbances. Do not dilute with electrolyte-containing solutions.

Essentiale N has undergone all required clinical trials and fully complies with international regulatory and certification standards.